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VB.NET打开二进制文件用fileopen完成，打开二进制文件的形式为：openmode.binary
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读取二进制文件用的是fileget方法，写入二进制文件用的是fileput方法。
应用示例：将一批随机数保存在一个dat文件中，然后再将其提取到文本框中。
二进制文件的读写一批随机数的存取，程序为：
Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click
Dim x, i, fn As Integer
Dim s As String = ""
fn = FreeFile()
FileOpen(fn, "d:\data.dat", OpenMode.Binary)
For i = 1 To 8
x = Int(Rnd() * 100)
s = s + Str(x)
FilePut(fn, x)
Next
FileClose(fn)
TextBox1.Text = s
End Sub
Private Sub Button2_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button2.Click
Dim x, fn As Integer
Dim s As String = ""
fn = FreeFile()
FileOpen(fn, "d:\data.dat", OpenMode.Binary)
Do While Not EOF(fn)
FileGet(fn, x)
s = s + Str(x) + " "
Loop
FileClose(fn)
TextBox1.Text = s
End Sub
写入：Dim sr As New IO.StreamWriter(Application.StartupPath "/写入的文本.txt")
sr.WriteLine("写入的内容") sr.Close()读取：If (File.Exists(Application.StartupPath "/msg.txt")) Then
Dim fm As New IO.FileStream(Application.StartupPath "/读取的文本.txt", FileMode.Open)
Dim sr As IO.StreamReader = New IO.StreamReader(fm)
Do While sr.Peek() = 0
TextBox1.Text = sr.ReadLine() （读取文本到文本框）
Loop end if
dim filename as string = "文件名" Using myfilestream As New FileStream(FileName, FileMode.Open, FileAccess.Read)
Dim data() As Byte
ReDim data(myfilestream.Length - 1)
myfilestream.Read(data, 0, myfilestream.Length)
myfilestream.Close()
' data是你要的结果，为byte()， End Using
1、新建一个标准的VB EXE工程，只有一个Form，Form上有两个按钮：Command1和Command2。
2、双击Command1添加如下代码
Private Sub Command1_Click()
Dim strFile As String
Dim intFile As Integer
Dim strData As String
strFile = "c:\学生成绩.txt"
intFile = FreeFile
Open strFile For Input As intFile
strData = StrConv(InputB(FileLen(strFile), intFile), vbUnicode)
Debug.Print strData
Close intFile
End Sub
3、按F8开始单步调试代码，点击Command1，进入单步调试功能，
4、多次按下F8或直接按下F5运行完成，就完成了读取文本文件内容并输出到立即窗口。