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方法一：调用系统DLL（这个有点不完善，也就是播放声音时窗体无法控制，效果相当于Enabled=true，但音频播放完毕后就没事了）
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Private Declare Function sndPlaySound Lib "Winmm.dll" Alias "sndPlaySoundA" (ByVal lpszSoundName As String, ByVal uFlags As Long) As Long
Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click
Dim SoundFile As String, Result As Long
SoundFile = "D:\KuGou\Pianoboy - 第105天.wav" '此处为路径
Result = sndPlaySound(SoundFile, 0)
End Sub
方法二：使用WindowsMediaPlayer（WindowsMediaPlayer1的可见为False）
先添加一个windowsmediaplayer控件（工具箱里没有，需要手动添加）
Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click
WindowsMediaPlayer1.visible=False
Me.WindowsMediaPlayer1.URL = "D:\KuGou\Pianoboy - 第105天.mp3"
End Sub
上面的都是点击button1（按钮1）后播放声音，若是鼠标移动到某控件上发出声音的话改一下触发事件就OK了。
用Console.Beep(int,int)这个方法就可以了。
另外，建议把提示出错的代码直接放入Catch中，提示鸣放的代码放入Try中。
给你我的程序，自己研究一下吧，我也不是很明白。
Public Class Form1
Private Declare Auto Function PlaySound Lib "winmm.dll" (ByVal lpszSoundName As String, ByVal hModule As Integer, ByVal dwFlags As Integer) As Integer
Const SND_filename As Integer = H20000
Const SND_alias As Integer = H10000
Const SND_sync As Integer = H0
Declare Auto Function waveOutGetNumDevs Lib "winmm.dll" Alias "waveOutGetNumDevs" () As Integer
Declare Auto Function sndPlaySound Lib "winmm.dll" (ByVal filename As String, ByVal options As Integer) As Integer
Private Const SND_memory As Integer = H4
Private Const SND_async As Integer = H1
Private Const proess_domain As String = ""
Const SND_sync1 = H0
Const SND_async1 = H1
Const SND_nodefault = H2
Const SND_loop = H8
Const SND_nostop = H10
Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click
Beep()
End Sub
Private Sub Button2_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button2.Click
Dim strFileName As String = "start.wav"
PlaySound(strFileName, 0, SND_filename)
End Sub
Private Sub Button3_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button3.Click
PlaySound("systemstart", 0, SND_alias Or SND_sync)
End Sub
Private Sub Button4_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button4.Click
Dim ret As Long
Dim strfilename As String
strfilename = "start.wav"
ret = sndPlaySound(strfilename.ToCharArray, 0)
End Sub
Private Sub Button5_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button5.Click
Dim i As Integer
i = waveOutGetNumDevs()
If i 0 Then
MsgBox("可以播放声音", 64, "检测")
Else
MsgBox("不能播放声音", 64, "检测")
End If
End Sub
End Class
两种方法
1.
Shell(""Explorer.exe", AppWinStyle.NormalFocus")
2.
Dim proc As New Process
proc.StartInfo.FileName="Explorer.exe"
proc.Start
方法2给予更多的控制，如结束进程的方法Kill
1.用Win32 API PlaySound
PlaySound位于"winmm.dll"中，可以根据输入参数的不同，播放WAV类型的音乐。在VB.NET中调用跟VB6中差不多：
先声明：
Private Declare Auto Function PlaySound Lib "winmm.dll" (ByVal lpszSoundName As String, ByVal hModule As Integer, ByVal dwFlags As Integer) As Integer
Const SND_FILENAME As Integer = H20000
Const SND_ALIAS As Integer = H10000
Const SND_SYNC As Integer = H0
具体还有很多常量，不一一列举，下面是播放一个wav文件的例子
Dim mstrfileName As String = "c:\eagle2.wav"
PlaySound(mstrfileName, 0, SND_FILENAME)
注意上面的播放是非同步的，就是说它并不会播放完毕才结束。如果把上面的代码写在一个Button.Click的事件处理程序中，第二次点击的时候它会打断第一次的播放，重新开始。
当然我们也可以调用系统的声音：
PlaySound("SystemStart", 0, SND_ALIAS Or SND_SYNC)
' 以同步的方式调用系统启动时候的声音。
2． 调用媒体播放器控件
VB.NET中并没有提供媒体播放器的.NET组件，没办法我们还是调用以前Com组件Windows Media Player。当然除了声音外，还可以播放视频文件。
首先把媒体播放器控件加到工具栏中，调用还是简单的写一下吧：）
Private Sub playMediaFile(ByVal mediaFileName As String)
With MediaPlayer1
.Stop()
.FileName = "c:\mp3\爱不爱我.mp3"
.Play()
End With
End Sub